Automated Glaucoma Detection Using Hybrid Feature Extraction in Retinal Fundus Images

Glaucoma is one of the most common causes of blindness. Robust mass screening may help to extend the symptom-free life for affected patients. To realize mass screening requires a cost-effective glaucoma detection method which integrates well with digital medical and administrative processes. To address these requirements, we propose a novel low cost automated glaucoma diagnosis system based on hybrid feature extraction from digital fundus images. The paper discusses a system for the automated identification of normal and glaucoma classes using higher order spectra (HOS), trace transform (TT), and discrete wavelet transform (DWT) features. The extracted features are fed to a support vector machine (SVM) classifier with linear, polynomial order 1, 2, 3 and radial basis function (RBF) in order to select the best kernel for automated decision making. In this work, the SVM classifier, with a polynomial order 2 kernel function, was able to identify glaucoma and normal images with an accuracy of 91.67%, and sensitivity and specificity of 90% and 93.33%, respectively. Furthermore, we propose a novel integrated index called Glaucoma Risk Index (GRI) which is composed from HOS, TT, and DWT features, to diagnose the unknown class using a single feature. We hope that this GRI will aid clinicians to make a faster glaucoma diagnosis during the mass screening of normal/glaucoma images

Automated detection of optic disk in retinal fundus images using intuitionistic fuzzy histon segmentation

The human eye is one of the most sophisticated organs, with perfectly interrelated retina, pupil, iris cornea, lens, and optic nerve. Automatic retinal image analysis is emerging as an important screening tool for early detection of eye diseases. Uncontrolled diabetic retinopathy (DR) and glaucoma may lead to blindness. The identification of retinal anatomical regions is a prerequisite for the computer-aided diagnosis of several retinal diseases. The manual examination of optic disk (OD) is a standard procedure used for detecting different stages of DR and glaucoma. In this article, a novel automated, reliable, and efficient OD localization and segmentation method using digital fundus images is proposed. General-purpose edge detection algorithms often fail to segment the OD due to fuzzy boundaries, inconsistent image contrast, or missing edge features. This article proposes a novel and probably the first method using the Attanassov intuitionistic fuzzy histon (A-IFSH)–based segmentation to detect OD in retinal fundus images. OD pixel intensity and column-wise neighborhood operation are employed to locate and isolate the OD. The method has been evaluated on 100 images comprising 30 normal, 39 glaucomatous, and 31 DR images. Our proposed method has yielded precision of 0.93, recall of 0.91, F-score of 0.92, and mean segmentation accuracy of 93.4%. We have also compared the performance of our proposed method with the Otsu and gradient vector flow (GVF) snake methods. Overall, our result shows the superiority of proposed fuzzy segmentation technique over other two segmentation methods

Application of intuitionistic fuzzy histon segmentation for the automated detection of optic disc in digital fundus images

Human eye is the most sophisticated organ, with perfectly interrelated subsystems such as retina, pupil, iris cornea, lens and optic nerve. Uncontrolled diabetes retinopathy (DR) and glaucoma may lead to blindness. Optic disc helps to identify the different stages of DR, and glaucoma. In this paper, a novel automated, reliable and efficient optic disc localization and segmentation method using digital fundus images is proposed. General-purpose edge detection algorithms often fail to segment the optic disc (OD) due to fuzzy boundaries, inconsistent image contrast or missing edge features. This paper proposes a novel and probably the first method, using Attanassov intuitionistic fuzzy histon (A-IFSH) based segmentation to segment optic disc in retinal fundus images. Optic disc pixel intensity and column wise neighbourhood operation is employed to locate and isolate the optic disc. The method has been evaluated on 100 images comprising 30 normal, 39 glaucomatous and 31 DR images. Our proposed method yielded precision-0.93, recall-0.91, F-score-0.92 and mean segmentation accuracy of 93.4%. We have also compared the performance of our proposed method with Otsu and Gradient vector flow (GVF) snake methods. Overall, our result shows the superiority of proposed fuzzy segmentation technique over other two segmentation methods

Atherosclerotic risk stratification strategy for carotid arteries using texture-based features

Plaques in the carotid artery result in stenosis, which is one of the main causes for stroke. Patients have to be carefully selected for stenosis treatments as they carry some risk. Since patients with symptomatic plaques have greater risk for strokes, an objective classification technique that classifies the plaques into symptomatic and asymptomatic classes is needed.We present a computer aided diagnostic (CAD) based ultrasound characterization methodology (a class of Atheromatic systems) that classifies the patient into symptomatic and asymptomatic classes using two kinds of datasets: (1) plaque regions in ultrasound carotids segmented semi-automatically and (2) far wall gray-scale intima-media thickness (IMT) regions along the common carotid artery segmented automatically. For both kinds of datasets, the protocol consists of estimating texture-based features in frameworks of local binary patterns (LBP) and Law's texture energy (LTE) and applying these features for obtaining the training parameters, which are then used for classification. Our database consists of 150 asymptomatic and 196 symptomatic plaque regions and 342 IMT wall regions. When using the Atheromatic-based system on semiautomatically determined plaque regions, support vector machine (SVM) classifier was adapted with highest accuracy of 83%. The accuracy registered was 89.5% on the far wall gray-scale IMTregions when using SVM, K-nearest neighbor (KNN) or radial basis probabilistic neural network (RBPNN) classifiers. LBP/LTE-based techniques on both kinds of carotid datasets are noninvasive, fast, objective and cost-effective for plaque characterization and, hence, will add more value to the existing carotid plaque diagnostics protocol.We have also proposed an index for each type of datasets: AtheromaticPi, for carotid plaque region, and AtheromaticWi, for IMT carotid wall region, based on the combination of the respective significant features. These indices show a separation between symptomatic and asymptomatic by 4.53 units and 4.42 units, respectively, thereby supporting the texture hypothesis classificatio

Automated diagnosis of cardiac health using recurrence quantification analysis

The sum total of millions of cardiac cell depolarization potentials can be represented using an electrocardiogram (ECG). By inspecting the P-QRS-T wave in the ECG of a patient, the cardiac health can be diagnosed. Since the amplitude and duration of the ECG signal are too small, subtle changes in the ECG signal are very difficult to be deciphered. In this work, the heart rate variability (HRV) signal has been used as the base signal to observe the functioning of the heart. The HRV signal is non-linear and non-stationary. Recurrence quantification analysis (RQA) has been used to extract the important features from the heart rate signals. These features were fed to the fuzzy, Gaussian mixture model (GMM), and probabilistic neural network (PNN) classifiers for automated classification of cardiac bio-electrical contractile disorders. Receiver operating characteristics (ROC) was used to test the performance of the classifiers. In our work, the Fuzzy classifier performed better than the other classifiers and demonstrated an average classification accuracy, sensitivity, specificity, and positive predictive value of more than 83%. The developed system is suitable to evaluate large datasets